Richard Gross
Professor
Chemical and Biomolecular Engineering
- Phone: (718) 260-3024
- Email: rgross@duke.poly.edu
- Location: RH 627
- Website:

Education
Polytechnic University, Class of 1986
Doctor of Philosophy, Organic-Polymer Chemistry
Research Interests
Research at the interface between polymers and the biological sciences.
Biosynthesis, biocatalysis and biotechnologyJournal Articles
2008
- Bo Chen, Jun Hu, Elizabeth M. Miller, Wenchun Xie, Minmin Cai, and Richard A. Gross, Candida antarctica Lipase B Chemically Immobilized on Epoxy-Activated Micro- and Nanobeads: Catalysts for Polyester Synthesis Biomacromolecules , 9, 463-471(2008).
2007
- Bo Chen, Elizabeth M. Miller, Lisa Miller, John J. Maikner, and Richard A. Gross, Effects of Macroporous Resin Size on Candida antarctica Lipase B Adsorption, Fraction of Active Molecules, and Catalytic Activity for Polyester Synthesis Langmuir , 23, 1381-1387(2007).
- Mo Hunsen, Abul Azim, Harald Mang, Sabine R. Wallner, Asa Ronkvist, Wenchun Xie, and Richard A. Gross, A Cutinase with Polyester Synthesis Activity Macromolecules , 40(2), 148-150(2007).
- Dodds, D. R.; Gross, R. A., Chemicals from biomass. Science, 318 (5854), 1250-1251 (2007).
- Sharma, B.; Azim, A.; Azim, H.; Gross, R. A., Enzymatic synthesis and solid-state properties of aliphatic polyesteramides with polydimethylsiloxane blocks. Macromolecules , 40(22), 7919-7927(2007).
- Jiang, Z. Z.; Liu, C.; Xie, W. C.; Gross, R. A., Controlled lipase-catalyzed synthesis of poly(hexamethylene carbonate). Macromolecules, 40 (22), 7934-7943 (2007).
- Hardin, R.; Pierre, J.; Schulze, R.; Mueller, C. M.; Fu, S. L.; Wallner, S. R.; Stanek, A.; Shah, V.; Gross, R. A.; Weedon, J.; Nowakowski, M.; Zenilman, M. E.; Bluth, M. H., Sophorolipids improve sepsis survival: Effects of dosing and derivatives. Journal of Surgical Research, 142 (2), 314-319 (2007).
- Fu, S. L.; Mueller, C.; Lin, Y. Y.; Viterbo, D.; Pierre, J.; Shah, V.; Gross, R.; Schulze, R.; Zenilman, M., Sophorolipid treatment decreases LIPS induced inflammatory responses and NO production in macrophages. Journal of the American College of Surgeons, 205 (3), S44-S44 (2007).
- Jiang, Z. Z.; Azim, H.; Gross, R. A.; Focarete, M. L.; Scandola, M., Lipase-catalyzed copolymerization of omega-pentadecalactone with p-dioxanone and characterization of copolymer thermal and crystalline properties. Biomacromolecules, 8 (7), 2262-2269 (2007).
- Kulshrestha, A. S.; Gao, W.; Fu, H. Y.; Gross, R. A., Synthesis and characterization of branched polymers from lipase-catalyzed trimethylolpropane copolymerizations. Biomacromolecules, 8 (6), 1794-1801 (2007).
- Chen, B.; Miller, M. E.; Gross, R. A., Effects of porous polystyrene resin parameters on Candida antarctica Lipase B adsorption, distribution, and polyester synthesis activity. Langmuir , 23 (11), 6467-6474 (2007).
- Hagler, M.; Smith-Norowitz, T. A.; Chice, S.; Wallner, S. R.; Viterbo, D.; Mueller, C. M.; Gross, R.; Nowakowski, M.; Schulze, R.; Zenilman, M. E.; Bluth, M. H., Sophorolipids decrease IgE production in U266 cells by downregulation of BSAP (Pax5), TLR-2, STAT3 and IL-6. Journal of Allergy and Clinical Immunology, 119 (1), S263-S263 (2007).
- Felse, P. A.; Shah, V.; Chan, J.; Rao, K. J.; Gross, R. A., Sophorolipid biosynthesis by Candida bombicola from industrial fatty acid residues. Enzyme and Microbial Technology, 40 (2), 316-323 (2007).
2006
- Wei Gao, Rena Hagver, Vishal Shah, Wenchun Xie, Richard A. Gross, M. Firat Ilker, Chrissy Bell, Kelly A. Burke, and E. Bryan Coughlin Glycolipid Polymer Synthesized from Natural Lactonic Sophorolipids by Ring-Opening Metathesis Polymerization Macromolecules , 40(2), 145(2006).
- Li, Geng; Vaidya, A; Viswanathan, K; Cui, JR; Xie, W.C.; Gao, W; Gross, R.A.; Rapid regioselective oligomerization of L-glutamic acid diethyl ester catalyzed by papain, Macromolecules 39 (23): 7915-7921 (2006).
- Bluth, M.H.; Kandil, E; Mueller, C.M.; Shah, V.; Lin, Y.Y.; Zhang, H; Dresner, L.; Lempert, L.; Nowakowski, M.; Gross, R; Schulze, R.; Zenilman, M.E. Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis, Critical Care Medicine 34 (1): 188-195 (2006).
- Sahoo, B; Bhattacharya, A.; Fu, H.Y.; Gao, W.; Gross, R.A. Influence of PEG end-group and molecular weight on its reactivity for lipase-catalyzed polyester synthesis BioMacromolecules 7 (4): 1042-1048 (2006).
- Mueller, C.M.; Viterbo, D.; Murray, P.J.; Shah, V.; Gross, R.; Schulze, R.; Zenilman, M.E.; Bluth, M.H. Sophorolipid treatment decreases inflammatory cytokine expression in an in vitro model of experimental sepsis. Faseb Journal 20 (4): A204-A204 Part 1, (2006).
- Shah, V.; Baldrian, P.; Eichlerova, I.; Dave, R.; Madamwar, D.; Nerud, F.; Gross, R. Influence of dimethyl sulfoxide on extracellular enzyme production by Pleurotus ostreatus. Biotechnology Letters 28 (9): 651-655 (2006).
- Hu, J; Gao, W.; Kulshrestha, A.; Gross, R.A. "Sweet polyesters": Lipase-catalyzed condensation - Polymerizations of alditols, Macromolecules 39 (20): 6789-6792 (2006).
- Azim, A; Shah, V.; Doncel, G.F.; Peterson, N.; Gao, W.; Gross, R. Amino acid conjugated sophorolipids: A new family of biologically active functionalized glycolipids. Bioconjugate Chemistry 17 (6): 1523-1529 (2006).
- Azim, H.; Dekhterman, A.; Jiang, Z.Z.; Gross, R.A. Candida antarctica lipase B-catalyzed synthesis of poly(butylene succinate): Shorter chain building blocks also work, BioMacromolecules 7 (11): 3093-3097 (2006).
2005
- Shah V, Doncel GF, Seyoum T, Eaton KM, Zalenskaya I, Hagver R, Azim A, Gross R. Sophorolipids, microbial glycolipids with anti-human immunodeficiency virus and sperm-immobilizing activities. Antimicrob Agents Chemother; 149; 1-8 (2005).
- Mijovic, J.; Bian, Y.; Gross, R. A.; Chen, B. Dynamics of Proteins in Hydrated State and in Solution As Studied by Dielectric Relaxation Spectroscopy Macromolecules; 38(26) 10812-10819 (2005).
- Chakraborty. S,Sahoo. B,Teraoka, Gross.RA Solution properties of starch nanoparticles in water and DMSO as studied by dynamic light scattering Carbohydrates polymers; 60(4); 475-481, (2005).
- Nakaoki, T.; Mei, Y.; Miller, L.-M.; Kumar, A; Kalra, B; Miller, E.-M.; Kirk, O.; Christensen, M.; Gross, R.A. " Candida antartica Lipase B catalyzed polymerization of lactones: Effects of immobilization matrices on polymerization kinetics and Molecular Weight" Industrial Biotechnology; 1(2) 126-134 (2005).
- Sahoo, B.; Brandstadt, K. F.; Lane, T. H.; Gross, R. A. " Sweet Silicones": Biocatalytic Reactions to Form Organosilicon Carbohydrate Macromers Org. Lett.; 7(18); 3857-3860 (2005).
- Loos, K.; Kennedy, S. B.; Eidelman, N.; Tai, Y.; Zharnikov, M.; Amis, E. J.; Ulman, A.; Gross, R. A. Combinatorial Approach To Study Enzyme/Surface Interactions Langmuir; 21(12); 5237-5241 (2005).
- Kulshrestha, A. S.; Sahoo, B., Gao, W.; Fu, H. and Gross, R.A. " Lipase Catalysis. A Direct Route to Linear Aliphatic Copolyesters of Bis(hydroxymethyl)butyric Acid with Pendant Carboxylic Acid Groups", Macromolecules; 38(8); 3205-3213 (2005).
- Kulshrestha, A. S.; Gao, W.; Gross, R.A. " Glycerol Copolyesters: Control of Branching and Molecular Weight Using a Lipase Catalyst", Macromolecules, (2005); 38(8); 3193-3204.
- Ceccorulli, G.; Scandola, M.; Kumar, A.; Kalra, B.; Gross, R. A., " Cocrystallization of Random Copolymers of -Pentadecalactone and -Caprolactone Synthesized by Lipase Catalysis" BioMacromolecules; 6(2); 902-907 (2005).
- Chakraborty, S.; Sahoo, B.; Teraoka, I.; Miller, L. M.; Gross, R. A. " Enzyme-Catalyzed Regioselective Modification of Starch Nanoparticles" Macromolecules; 38(1); 61-68 (2005).
2004
- Zhang, L., Somasundaran, P., Singh, S. K., Felse, A. P., Gross, R.A. Synthesis and interfacial properties of sophorolipid derivatives Colloids and Surfaces A: Physicochem.Eng. Aspects; 240; 75-82 (2004).
- Zhou, S., Xu, Chang.., Wang, J., Gao, W., Akhverdiyeva., Shah, V., Gross, R. A. Supramolecular Assembles of a Naturally Derived Sopholipid. Langmuir; 20; 7926-7932 (2004).
- Kalra, B.; Kumar, A.; Gross, R. A.; Baiardo, M.; Scandola, M. " Chemoenzymatic Synthesis of New Brush Copolymers Comprising Poly( -pentadecalactone) with Unusual Thermal and Crystalline Properties" Macromolecules; 37(4); 1243-1250 (2004).
- Mahapatro, A.; Kumar, A.; Kalra, B.; Gross, R. A. " Solvent-Free Adipic Acid/1,8-Octanediol Condensation Polymerizations Catalyzed by Candida antartica Lipase B" Macromolecules; 37(1); 35-40 (2004).
- Van As, B. A. C.; Thomassen, P.; Kalra, B.; Gross, R. A.; Meijer, E. W.; Palmans, A. R. A.; Heise, A. " One-Pot Chemoenzymatic Cascade Polymerization under Kinetic Resolution Conditions" Macromolecules; 37(24); 8973-8977 (2004).
- Mahapatro, A.; Kumar, A.; Gross, R. A.; " Mild, Solvent-Free -Hydroxy Acid Polycondensations Catalyzed by Candida antarctica Lipase B." BioMacromolecules; 5(1); 62-68 (2004).
- Loeker, F. C.; Duxbury, C. J.; Kumar, R.; Gao, W.; Gross, R. A.; Howdle, S. M. Enzyme-Catalyzed Ring-Opening Polymerization of -Caprolactone in Supercritical Carbon Dioxide. Macromolecules; 37(7); 2450-2453 (2004).
- Hyung-Pil, S, Chung, C.H., Kim, S.K., Gross, R.A., Kaplan., D.L. Lee, J.W. Mass Production of Pullulan with Optimized Concentrations of Carbon and Nitrogen sources by Aureobasidium pullulans HP-2001 in a 100-L Bioreactor" J. Microbol. Biotechnol.; 14,(2), 237-242 (2004).
- Mei, Y., Kumar, A, Gao, W, Gross, R.A., Kennedy, S.B., Washburn, N.R., Amis, E,.J., Elliot, John T. Biocompatibility of sorbitol-containing polyesters. Part 1: Synthesis, surface analysis and cell response in vitro; Biomaterials; 25; 4195-4201 (2004).
2003
- Singh, S,K, Felse, A. P., Nunez, A., Foglia, T.A. and Gross, R.A. Regioselective Enzyme-Catalyzed Synthesis of Sophorolipid Esters, Amides and Multifunctional Monomers. J. Org. Chem.; 68; 5466-5477 (2003).
- Kumar, A.; Kulshrestha, A. S.; Gao, W.; Gross, R. A.; Versatile Route to Polyol Polyesters by Lipase Catalysis Macromolecules; 36(22); 8219-8221 (2003).
- Mei, Y.; Miller, L.; Gao, W.; Gross, R. A.; Imaging the Distribution and Secondary Structure of Immobilized Enzymes Using Infrared Microspectroscopy BioMacromolecules; 4(1); 70-74 (2003).
- Mahapatro, A.; Kalra, B.; Kumar, A.; Gross, R. A.; Lipase-Catalyzed Polycondensations: Effect of Substrates and Solvent on Chain Formation, Dispersity, and End-Group Structure BioMacromolecules; 4(3); 544-551 (2003).
- Fu, H.; Kulshrestha, A. S.; Gao, W.; Gross, R. A.; Baiardo, M.; Scandola, M., Physical Characterization of Sorbitol or Glycerol Containing Aliphatic Copolyesters Synthesized by Lipase-Catalyzed Polymerization Macromolecules; 36(26); 9804-9808 (2003).
- Dyal, A., Loos, Katja., Noto, M., Chang, S.W., Spagnoli, C., Shafi, Kurikka V.P.M., Ulman, A., Cowman,M.,Gross. R.A. Activity of Candida rugosa Lipase Immobilized on ?-Fe2O3 Magnetic Nanoparticles J. Am. Chem. Soc.; 125; 1684-1685 (2003).
- Mei, Y, Kumar, A, Gross; R.A., " Kinetics and Mechanism of Candida antarctica Lipase B Catalyzed Solution Polymerization of -Caprolactone", Macromolecules; 36(15); 5530-5536 (2003).
2002
- Gross, R. A., Kalra, B; " Biodegradable Polymers for the Environment", Science, 297, 803-806 (2002).
- Focarete, M. L.; Gazzano, M.; Scandola, M.; Kumar, A.; Gross, R. A.; " Copolymers of ?-Pentadecalactone and Trimethylene Carbonate from Lipase Catalysis: Influence of Microstructure on Solid-State Properties", Macromolecules; 35(21); 8066-8071, (2002).
- Kumar, A.; Gross, R. A.; Wang, Y.; Hillmyer, M. A.; " Recognition by Lipases of ?-Hydroxyl Macroinitiators for Diblock Copolymer Synthesis" Macromolecules; 35(20); 7606-7611, (2002).
- Kumar, R.; Gao, W.; Gross, R. A.; " Functionalized Polylactides: Preparation and Characterization of [L]-Lactide-co-Pentofuranose" Macromolecules; 2002; 35(18); 6835-6844.
- Bankova, M.; Kumar, A.; Impallomeni, G.; Ballistreri, A.; Gross, R. A.; " Mass-Selective Lipase-Catalyzed Poly(?-caprolactone) Transesterification Reactions", Macromolecules; 35(18); 6858-6866, (2002).
- Hu, Shanghui; Gupta, Pankaj; Prasad, Ashok K.; Gross, Richard, A., Parmar, Virinder S. " Selective enzymatic epoxidation of dienes: Generation of Functional Enantiomerically Enriched Diene Monoepoxy Monomers", Tetrahedron Letters; 43; 6763-6766 (2002).
- B. Kalra and R.A. Gross, " HRP-Mediated Polymerizations of acrylamide and sodium acrylate", Green Chemistry; 4; 174-178 (2002).
- Y. Mei, A. Kumar, and Richard A. Gross, " Probing Water-Temperature Relationships for Lipase-Catalyzed Lactone Ring-opening Polymerizations" Macromolecules; 35, 5444-5448 (2002).
- R. Kumar and R.A. Gross, " Biocatalytic Route to Well-Defined Macromers Built around a Sugar Core, J. Am. Chem. Soc., 124(9): 1850-1851 (2002).
- V Guilmanov, A Ballistreri, G Impallomeni, R.A. Gross, " Oxygen Transfer Rate and Sophorose Lipid Production by Candida bombicola", Biotechnol. and Bioeng; 77(5), 489-494 (2002).
2001
- R. A. Gross, A Kumar, B Kalra, "In-vitro Enzyme Catalyzed Polymer Synthesis", Chemical Reviews, 101(7), 2097-2124 (2001).
- J.W. Lee, F. Dang, W.G. Yeomans, A.L. Allen, R.A. Gross, D.L. Kaplan, " Acetobacter xylinium ATCC 10245: Production of Chitosan-Cellulose and Chitin-Cellulose Exopolymers, Applied and Environmental Microbiology, 67(9), 3970-3975 (2001).
- M. L. Focarete, A. Kumar, M. Scandola, R. A. Gross, "Physical Characterization of Poly(w-pentadecalactone) Synthesized by Lipase-Catalyzed Ring-Opening Polymerization", J of Polymer Science, Part B: Polymer Physics, 39(15), 1721-1729 (2001).
- R.A.Gross, B.Kalra, A. Kumar "In-vitro Lipase Catalyzed Polyester and Polycarbonate Synthesis" Applied Microbiology and Biotechnology; 55(6), 655-660 (2001).
- A Kumar, K Garg, R. A. Gross, "Lipase-Catalyzed Copolymerizations of Trimethylene Carbonate and w-Pentadecalactone" Macromolecules; 34; 3527-3533 (2001).
2000
- A Kumar, R.A Gross, " Lipase-Catalyzed Transesterification: New Synthetic Routes To Copolyesters", J. Am. Chem. Soc.; 122; 11767-11770 (2000).
- A Kumar, B Kalra, A Dekhterman, R. A. Gross, " Efficient Ring-opening Polymerization and Co-polymerization of ?-Caprolactone and ?-Pentadecalactone Catalyzed by Candida Antartica Lipase B", Macromolecules, 33, 6303-6309 (2000).
- K.S. Bisht, W Gao, R.A. Gross, " Glycolipids from Candida Bombicola: Polymerization of 6-O-Acryl Sophorolipid Derivative", Macromolecules, 33, 6208-6210 (2000).
- A. Kumar, R.A.Gross, J.D.Jenderoseck, " Poly(3-hydroxybutrate)-depolymerase from Pseudomonas Lemoignei: catalysis of esterification in organic media"Journal of Organic Chemistry, 65, 7800-7806 (2000).
- B Kalra, R.A. Gross, " HRP-Mediated Free Radical Polymerization of Methyl Methacrylate", BioMacromolecules, 1, 501-505 (2000).
- A Kumar and R.A. Gross, " Candida antartica Lipase B Catalyzed Polycaprolactone Synthesis: Effects of Organic Media and Temperature, BioMacromolecules, 1, 133-138 (2000).
Before 2000
- J.W. Lee, W.G. Yeomans, A.L. Allen, F. Deng, R.A. Gross and D.L. Kaplan, " Biosynthesis of Novel Exopolymers by Aureobasidium pullulans", Appl. & Env. Microbiol. 65(12), 5265-5271 (1999).
- A. Gorkovenko, J. Zhang, R. A. Gross, D. L. Kaplan, A. L. Allen. Control of unsaturated fatty acid substituents in emulsans. Carbohydrate Polymers. 39,79-84 (1999).
- R. D. Ashby, F.-Y. Shi and R.A. Gross, " A Tunable Switch to Regulate the Synthesis of Low and High Molecular Weight Microbial Polyesters" Biotechnology and Bioengineering, Vol. 62 (1), (1999).
- K. Bisht, R. Gross and D. Kaplan, " Enzyme-Mediated Regioselective Acylations of Sophorolipids", J. Org. Chem., 64:3, 780-789 (1999).
- X. Chen and R. Gross, " Versatile Copolymers from [L]-Lactide and [D]-Xylofuranose", Macromolecules, 32, 308-314 (1999).
- K. S. Bisht, F. Deng, R. A. Gross, D. L. Kaplan and G. Swift, " Ethyl Glucoside as a Multifunctionl Initiator for Enzyme-Catalyzed regioselective Lactone Ring-opening Polymerization" J. Am. Chem. Soc., Vol. 120, 1363-1367 (1998).
- K. S. Bisht, R. A. Gross and A. L. Cholli, " Enzymatic Polymerization of Poly(?-CL) Containing an Ethyl Glucopyranoside Head Group: An NMR Study" Applied Spectroscopy, 52 (11) 1472-1478, (1998).
- Young Ko and Richard A. Gross, " ?-Poly(glutamic acid) Formation by Bacillus licheniformis ATCC 9945a: Physiological Effects of glucose and glycerol", Biotechnol. and Bioeng., 57(40), 430-437 (1998).
- D. L. Kaplan, J. Dordick, R. A. Gross, G. Swift. In Enzymes in Polymer Science, R. Gross, D. Kaplan, G. Swift, Editors; American Chemical Society Symposium Series 684: 2-17 (1998).
- Kirpal S. Bisht, Lori A. Henderson, Yuri Y. Svirkin and Richard A. Gross, David L. Kaplan and Graham Swift, " Monomer and Polymer Synthesis by Lipase-Catalyzed Ring-Opening Reactions", In, Enzymes in Polymer Synthesis, Eds. R.A. Gross, D.L. Kaplan and G. Swift, ACS Symposium Series 684, ACS, Washington, 90-111 (1998).
- Xianhai Chen, Stephen P. McCarthy and Richard A. Gross, " Preparation and Characterization of Polycarbonates from 2,4,8,10-Tetraoxaspiro[5,5]undecane-3-one (DOXTC)-Trimethylenecarbonate (TMC) Ring-Opening Polymerizations, J. Appl. Polym. Sci., Vol. 67, 547-557 (1998).
- Xianhai Chen, Stephen P. McCarthy and Richard A. Gross, " Synthesis, Characterization and Epoxidaion of an Aliphatic Polycarbonate from 2,2-[4,4-cyclohexene-1]-trimethylene tcarbonate (cHTC) Ring-Opening Polymerization", Macromolecules; 30, 3470-3476 (1997).
- Fengying Shi, Richard D. Ashby and Richard A. Gross, " Formation by Alcaligenes species of Microbial Polyesters Containing 3-Hydroxybutyrate and 4-Hydroxybutyrate Repeat Units: Investigation of Product Homogeneity", Macromolecules, Vol. 30, 2521-2523 (1997).
- Richard Ashby, Feng-Ying Shi, and Richard A. Gross, " Use of poly(ethylene glycol) to control the end group structure and molecular weight of poly(3-hydroxybutyrate) formed by Alcaligenes latus DSM 1122," Tetrahedron, Vol 53, No. 45, 15209-115223 (1997).
- Kirpal S. Bisht, Yuri Y. Svirkin, Lori A. Henderson, Richard A. Gross, David L. Kaplan and Graham Swift, " Lipase-Catalyzed Ring-Opening Polymerization of Trimethylene Carbonate, Macromolecules, Vol. 30, 7735-7742 (1997).
- Jin W. Lee, Water G. Yeomans, Alfred L. Allen, David L. Kaplan, and Richard A. Gross, " Microbial production of water-soluble non curdlan type exopolymer-B with controlled composition by Agrobacterium sp. ATCC 31749" Biotechnol. Lett., 19(12), 1217-1221 (1997).
- Jin W. Lee, Water G. Yeomans, Alfred L. Allen, David L. Kaplan, and Richard A. Gross. " Production of zoogloea gum by Zoogloea ramigera with glucose analogs" Biotechnol. Lett. 19(8), 799-802 (1997).
- Kirpal S. Bisht, Lori A. Henderson, Richard A. Gross, David L. Kaplan and Graham Swift, " Enzyme-Catalyzed Ring-Opening Polymerization of Poly(?-pentadecalactone)", Macromolecules, Vol. 30, 2705-2711 (1997).
- Jin W. Lee, Water G. Yeomans, Alfred L. Allen, David L. Kaplan, Frank Deng, and Richard A. Gross. Exopolymers from curdlan production-incorporation of glucose-related sugars by Agrobacerium sp. ATCC 31749. Can. J. Microbiol. 43:149-156. (1997).
- Jinwen Zhang, Alexander Gorkovenko, Richard A. Gross, Alfred L. Allen and David L. Kaplan " Incorporation of 2-Hydroxyl Fatty Acids by Acinetobacter calcoaceticus RAG-1 to Tailor Emulsan Structure, Intern. J. Biol. Macromol.,Vol. 20, 9-21 (1997).
- Alexander Gorkovenko, Jinwen Zhang, Richard A. Gross, Alfred L. Allen and David L. Kaplan, " Bioengineering of Emulsifier Structure: Emulsan Analogs", Can. J. Microbiol, Vol. 43, 384-390 (1997).
- Renée T. Macdonald, Stephen P. McCarthy and Richard A. Gross, " Enzymatic Degradability of Poly(lactide): Effects of Chain Stereochemistry and Material Crystallinity", Macromolecules, Vol. 29, 7356-7361 (1996).
- Lori A. Henderson, Yuri, Y. Svirkin, Richard A. Gross, David L. Kaplan and Graham Swift, " Enzyme Catalyzed Polymerizations of ?-caprolactone: Effects of Initiator on Product Structure, Propagation Kinetics, and Mechanism", Macromolecules, Vol. 29, 7759-7766 (1996).
- David S. Roesser, Stephen P. McCarthy, Richard A. Gross and David L. Kaplan, "Effects of Substitution Site on Acetyl Amylose Biodegradability by Amylase Enzymes", Macromolecules, Vol. 29, No. 1, 1-9 (1996).
- Feng-Ying Shi, Richard Ashby and Richard A. Gross, "Use of Poly(ethylene glycol)s to Regulate Poly(3-hydroxybutyrate) Molecular Weight during Alcaligenes eutrophus Cultivations", Macromolecules, Vol. 29, 7753-7758 (1996).
- Feng-Ying Shi, Denise Rutherford and Richard A. Gross, "Microbial Polyester Synthesis: Effects of Poly(ethylene glycol) on Product Composition, Repeat Unit Sequence and End Group Structure", Macromolecules, Vol. 29, 10-17 (1996).
- Richard A. Gross, Oh-young Kim, Denise R. Rutherford and Richard A. Newmark, " Cyanophenoxy-Containing Microbial Polyesters: Structural Analysis, Thermal Properties, Second Harmonic Generation and In-Vivo Biodegradability", Polym. International, Vol. 39, 205-213 (1996).
- Jin Xu, Stephen P. McCarthy and Richard A. Gross, " Racemic ?-Methyl-?-propiolactone Polymerization by Organometallic Catalyst Systems", Macromolecules, Vol. 29, No. 13, 4565-4571 (1996).
- Anne-Marie Cromwick, Gregory A. Birrer and Richard A. Gross, " Effects of pH and Aeration on ?-Poly(glutamic acid) Formation by Bacillus licheniformis in Controlled Batch Fermenter Cultures", Biotechnol. Bioeng., Vol. 50, 222-227 (1996).
- Oh-young Kim, Richard A. Gross, W. James Hammar and Richard A. Newmark, " Microbial Synthesis of Poly(?-hydroxyalkanoates) Containing Fluorinated Side-Chain Substituents", Macromolecules, Vol. 29, No. 13, 4572-4581 (1996).
- Jin Xu, Richard A. Gross, David L. Kaplan and Graham Swift, " Chemoenzymatic Synthesis and Study of Poly(?-methyl-?-propiolactone) Stereocopolymers", Macromolecules, Vol. 29, No. 13, 4582-4590 (1996).
- Jin Xu, Richard A. Gross, David L. Kaplan and Graham Swift, " Chemoenzymatic Route to Poly(3-hydroxybutyrate)", Macromolecules, Vol. 29, 3857-3861 (1996).
- Jin Xu, Stephen P. McCarthy, Richard A. Gross and David L. Kaplan " Chitosan Film Acylation and Effects on Biodegradability", Macromolecules, Vol. 29, 3436-3440 (1996).
- Yuri Y. Svirkin, Jin Xu, Richard A. Gross, David L. Kaplan and Graham Swift, " Enzyme-Catalyzed Stereoselective Ring-Opening Polymerization of ?-Methyl-?-propiolactone", Macromolecules, Vol. 29, No. 13, 4591-4597 (1996).
- Zbigniew Jedlinski, Marek Kowalczuk, Piotr Kurcok, Grazyna Adamus, Andrzej Matuszowicz, Wanda Sikorska, Richard A. Gross, Jin Xu, and Robert W. Lenz, " Stereochemical Control in the Anionic Polymerization of ?-Butyrolactone Initiated with Alkali-Metal Alkoxides", Macromolecules, Vol. 29, 3773-3777 (1996).
- Oh-young Kim, Richard A. Gross and Denise R. Rutherford, " Bioengineering of Poly(?-hydroxyalkanoates) for Advanced Material Applications: Incorporation of Cyano- and Nitrophenoxy Side Chain Substituents", Can. J. Microbiol., Vol. 41, supplement 1, 32-43 (1995).
- Ferdinando F. Bruno, Joseph A. Akkara, Madhu Ayyagari, David L. Kaplan, Richard A. Gross, Graham Swift and Jonathan S. Dordick, " Enzymatic Modification of Insoluble Amylose in Organic Solvents", Macromolecules, Vol. 28, 8881-8883 (1995).
- Renée T. Macdonald, Satish K. Pulapura, Yuri Y. Svirkin and Richard A. Gross, "Enzyme Catalyzed ?-Caprolactone Ring-Opening Polymerization", Macromolecules, 28, 73-78 (1995).
- Anne-Marie Cromwick and Richard A. Gross, "Effects of Manganese (II) on Bacillus licheniformis ATCC 9945A Physiology and ?-Poly(glutamic acid) Formation, Int. J. Biol. Macromol., Vol 17, No. 5, 259-267 (1995).
- Anne-Marie Cromwick and Richard A. Gross, "Investigation by NMR of Metabolic Routes to Bacterial ?-Poly(Glutamic Acid) Using 13C Labeled Citrate and Glutamate as Media Carbon sources, Can. J. Microbiol., Vol 41: 902-909 (1995).
- Richard A. Gross, Ji-Dong Gu, David Eberiel and Stephen P. McCarthy, "Laboratory Scale Composting Test Methods to Determine Polymer Biodegradability: Model Studies on Cellulose Acetate, J Macromol. Sci.-Pure & Appl. Chem., V A32, No. 4, 613-628 (1995).
- John E. Kemnitzer, Stephen P. McCarthy, Richard A. Gross, John Liggat, David J. Blundell and Mike Cox, "Crystallization Behavior of Predominantly Syndiotactic Poly(?-hydroxybutyrate)", J. Environ. Polym. Deg. Vol. 3(1), 37-47 (1995).
- Gregory A. Birrer, Anne-Marie Cromwick and Richard A. Gross, "?-Poly(glutamic acid) Formation by Bacillus licheniformis ATCC 9945A: Physiology and Biochemical Studies, Int. J. Biol. Macromol. ; 16(5) 265-275 (1994).
- Ji-Dong Gu, Shunjuan Yang, Robert Welton, David Eberiel, Stephen P. McCarthy and Richard A. Gross, "Effect of Environmental Parameters on the Degradability of Polymer Films in Laboratory Scale Composting Reactors", J. Environ. Polym. Deg., Vol 2, No. 2, 129-135 (1994).
- Deeleep K. Rout, Shikha P. Barman, Satish K. Pulapura, and Richard A. Gross, "Cholesteric Mesophases Formed by the Modified Biological Macromolecule 3,6-O-(Buyl Carbamate)-N-phthaloyl Chitosan, Macromolecules, Vol. 27, 2945-2950 (1994).
- Michael S. Reeve, Stephen P. McCarthy, Milton J. Downey and Richard A. Gross, "Polylactide Stereochemistry: Effect on Enzymatic Degradability, Macromolecules, Vol. 27, 825-831 (1994).
- Richard A. Gross, "Bacterial Polyesters: Structural Variability in Microbial Synthesis", in Biomedical Polymers: Designed-to-Degrade Systems, Ed. S. Shalaby, Hanser Publishers, NY, pgs. 2-19 (1994).
- Herbert W. Ulmer, Richard A. Gross, Mario Posada, Paul Weisbach, R. Clinton Fuller and Robert W. Lenz, "Bacterial Production of Poly(?-hydroxyalkanoates) Containing Unsaturated Repeating Units by Rhodospirillum rubrum, Macromolecules, Vol 27, 1675-1679 (1994).
- Ji-Dong Gu, David Eberiel, Stephen P. McCarthy and Richard A. Gross, "Degradation and Mineralization of Cellulose Acetate in Simulated Thermophilic Compost Environments", J. Environ. Polym. Deg., Vol 1, No. 4, 281- 291 (1993).
- Ji-Dong Gu, Sarah Coulter, David Eberiel, Stephen P. McCarthy and Richard A. Gross, "A Respirometric Method to Measure Mineralization of Polymeric Materials in a Matured Compost Environment", J. Environ. Polym. Deg., Vol 1, No. 4, 293- 299 (1993).
- Richard A. Gross, Gregory A. Birrer, Anne-Marie Cromwick, Stephen A. Giannos and Stephen P. McCarthy, "Polymers From Biotechnology: Bacterial Polyesters and ?-Poly(glutamic Acid)", in Biotechnological Polymers: Medical, Pharmaceutical and Industrial Applications, Ed. C. G. Gebelin, Technomic Publishing Co., PA, pgs. 200-213 (1993).
- Deeleep K. Rout, Satish K. Pulapura and Richard A. Gross, "Gel-Sol Transition and Thermotropic Behavior of a Chitosan Derivative in Lyotropic Solution", Macromolecules, Vol 26., 6007-6010 (1993).
- Deeleep K. Rout, Satish K. Pulapura and Richard A. Gross, "Liquid Crystalline Characteristics of Site-Selectively-Modified Chitosan", Macromolecules, Vol. 26, 5999-6006 (1993).
- John E. Kemnitzer, Stephen P. McCarthy, and Richard A. Gross, "Syndiospecific Ring-Opening Polymerization of ?-Butyrolactone to Form Predominantly Syndiotactic Poly(?-hydroxybutyrate) Using Tin (IV) Catalysts", Macromolecules, Vol. 26, 6143-6150 (1993).
- John E. Kemnitzer, Stephen P. McCarthy, and Richard A. Gross, "The Preparation of Predominantly Syndiotactic Poly(?-hydroxybutyrate) by the Tributyl Methoxide Catalyzed Ring-Opening Polymerization of Racemic ?-Butyrolactone " Macromolecules, Vol. 26, pgs. 1221-1229 (1993).
- Michael S. Reeve, Stephen P. McCarthy and Richard A. Gross, "The Preparation and Characterization of [R]-Poly(?-hydroxybutyrate)-Poly(?-Caprolactone) and [R]-Poly(?-hydroxybutyrate)-Poly(lactide) Degradable Diblock Copolymers", Macromolecules, Vol. 26, pgs. 888-894 (1993).
- Ji-Dong Gu, David. T. Eberiel, Stephen. P. McCarthy and Richard. A. Gross, "Cellulose Acetate Biodegradability Upon Exposure To Simulated Aerobic Composting And Anaerobic Bioreactor Environments", J Environ. Polym. Degrad., 1(2), (1993).
Biography
Richard A. Gross has more than 22 years experience working at the interface between biocatalysis, chemistry, and polymers. He has held faculty positions at the University of Massachusetts (Lowell campus) and the Polytechnic Institute of New York University (NYU-Poly), where he is the Herman F. Mark Professor. His research has primarily focused on both whole cell and immobilized enzyme routes to polymers and surfactants. He was President of the U.S. Society for Biodegradable Plastics in 1998 and is well known as a leader in that field. In 2003, he received the Presidential Green Chemistry award for his work on biocatalytic routes to polymers.
In 2001, he founded the National Science Foundation Industrial/University Cooperative Research Center for Biocatalysis and Bioprocessing of Macromolecules at NYU-Poly, and he continues to serve as Director. It has enjoyed the participation of numerous industrial partners. He has more than 360 publications in peer-reviewed journals, which have cited about 6,000 times. He edited five books, and has been granted or filed a total of 19 patents. His career awards and professional activities include the National Science Foundation Presidential Young Investigator Award, President of the U.S. Society on Biodegradable Polymers, and founder of the Journal of Environmental Polymer Degradation. His research group at NYU-Poly typically consists of about 25 members including 10 doctoral students and 5 postdoctoral fellows.
Dr. Gross is the inventor of the concept of biobased ω-hydroxyfatty acid monomers and their polymers from triglyceride feedstocks. He discovered new technological approaches for amplifying the biological activity and fine-tuning the physico-mechanical properties of surfactants produced by microbes. He founded the New York-based company SyntheZyme in 2008 to pursue major opportunities in developing biocatalytic routes to bio-based monomers, polymers, and surfactants. At SyntheZyme, he leads the core biocatalytic chemistry technology and discovery group.
He received his PhD at Polytechnic University (now NYU-Poly) in 1986 in organic-polymer chemistry and was a postdoctoral fellow with Bob Lenz and Clint Fuller at University of Massachusetts Amherst (1986-1988) working on bacterial polyester.