Jin Kim Montclare
Assistant Professor
Chemical and Biological Science
- Phone: (718) 260-3679
- Email: jmontcla@poly.edu
- Website: http://faculty.poly.edu/~jmontcla/
http://research.poly.edu/~cbtl/
http://faculty.poly.edu/~cbas/
Education
Yale University, Class of 2003
MS, PhD, Bioorganic Chemistry
Fordham University, Class of 1997
BS, Chemistry
Experience
NYU-Poly
Assistant Professor
The Protein Engineering and Molecular Design Lab began July 2005. Broadly, our lab is focused on engineering macromolecules. The long-term goal of our lab research is to be able to predictably design or engineer artificial therapeutics, biocatalysts, scaffolds and cells. We seek to provide biologically inspired solutions to address the challenges of human disorder treatment and medicine, sustainable energy and environmental remediation.
From: July 2005 to present
California Institute of Technology
Postdoctoral fellow
Worked in the laboratory of Professor David Tirrell on evolving proteins bearing unnatural amino acids.
From: January 2003 to present
Courses Taught
Summer 2009 Guided Studies for Biomedical Engineering (BE 873) Spring 2009 Protein Engineering (CM 943) P Fall 2008 Guided Studies for Biomedical Engineering (BE 873) Fall 2008 Undergraduate Research (BMS 4924) Fall 2008 Genetics (BMS 3114) Summer 2008 Guided Studies for Biomedical Engineering (BE 873) Summer 2008 Thesis for Biomedical Science (BE 977X) Summer 2008 Guided Studies for Biotechnology (BT 8713) Spring 2008 Protein Engineering (CM 943) Spring 2008 Senior Project Research (BMS 4924) Spring 2008 MS Thesis for Biomedical Engineering (BE 873) Fall 2007 Genetics (BMS 3114) Fall 2007 Senior Project Research (BMS 4914) Fall 2007 MS Thesis for Biomedical Engineering (BE 873) Spring 2007 Protein Engineering (CM 943) Spring 2007 Senior Project Research (BMS 4924) Spring 2007 Topics in Biology (BMS 4800) Fall 2006 Senior Project Research (BMS 4914) Spring 2006 Protein Engineering (CM 945) Spring 2006 Senior Project Research (LS 4924) Spring 2006 Senior Project Research (CM 4924) Spring 2006 Topics in Biology (BMS 4800) Spring 2006 MS Thesis for Biomedical Engineering (BE 874) Fall 2005 Genetics (BMS 3114) Fall 2005 Senior Project Research (BMS 4914) Fall 2005 Senior Project Research (CM 4914) Fall 2005 MS Thesis for Biomedical Engineering (BE 873)
Research Interests
protein engineering chemical biology biomaterials self-assembly artificial proteins biocatalyis
Awards + Distinctions
- 2009 Young Observer Fellowship (declined)
- 2008 ACS PROGRESS/Dreyfus Lectureship
- 2008 Dreyfus Special Grants Program Award
- 2007 AFOSR Young Investigator Award
- 2006 Wechsler Award for Excellence
- 2006 Othmer Junior Fellow, Othmer Institute
- 2003-2005 National Institute of Health Postdoctoral Fellowship
- 2001 T. F. Cooke Teaching Award for Organic Chemistry; Yale University
- 1997-2000 National Science Foundation Graduate Research Fellowship
- 1997-2000 Pfizer Fellowship
Event Participation
Jin K. Montclare Nanoscaled Biocatalysts and Self-Assembling Protein Polymers. Invited Speaker, March 12, 2009, Department of Chemistry, Boston College, Boston, MA. Jin K. Montclare Bio-Inspired Macromolecules through Protein Engineering. Invited Speaker, March 10, 2009, Department of Chemistry, Tufts University, Medford, MA. Jin K. Montclare Nanoscaled Biocatalysts and Self-Assembling Protein Polymers. Invited Speaker, February 20, 2009, Department of Chemistry, Hunter College, NY, NY. Jin K. Montclare Tailoring Bioinspired Macromolecules. Invited Speaker, February 12, 2009, Department of Chemistry, SUNY Stoney Brook, Long Island, NY. Jin K. Montclare Bioinspired Macromolecules: Designing Artificial Proteins. Invited Speaker, January 22, 2009, NYSBDG, NYAS, New York, NY. Jin K. Montclare Design and Characterization of Self-Assembling Protein Block Polymers. Invited Speaker, January 9, 2009, 2009 Natural Materials, Systems and Extremophiles, Arlington, VA. Jin K. Montclare Bio-related Polymers. Invited Speaker, December 12, 2008, NYU Chemistry Club, New York, NY. Jin K. Montclare Tailoring Artificial Functional Macromolecules. Invited Speaker, December 8, 2008, Department of Chemistry, CCNY, New York, NY. Jin K. Montclare Bioinspired Macromolecules: Designing Artificial Proteins. Invited Speaker, November 18, 2008, Department of Chemistry and Environmental Engineering, NJIT, Newark, NJ. Jin K. Montclare Bioinspired Macromolecules: Designing Artificial Proteins. Invited Speaker, November 14, 2008, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE.
Hometown
Bronx, NY
Affiliations
SUNY Downstate Medical Center Rockefeller University
Grants
NYU:Poly Seed Grant, ()
NYS DOE, ()
NSF, ()
MRI: Development of Ring-Ribbon Resonator Biosensor Instrument, (co-PI)
Mentored Chem-Bio Technology Lab: from virtual small molecules to, (PI)
High Throughput Instrumentation System for the Streamlined Synthe, (PI)
Engineered Protein Polymers, (PI)
Camille and Henry Dreyfus Foundation, ()
AFOSR DURIP, ()
AFOSR, ()
General / Collaborative Research
- Rich Gross, NYU:Poly CBAS group: Jin Kim, Rasti Levicky, Maurizio Porfiri and Stavroula Sofou, NYU:Poly Jasna Brujic: NYU Xiang-Peng Kong: NYU Medical School
- Jasna Brujic, Physics (NYU)
- Xiang-Peng Kong, NYU Med
- Seiichi Yamano, NYU Dental
Journal Articles
- Natalya Voloshchuk & Jin K. Montclare, Incorporation of unnatural amino acids for synthetic biology. Mol. BioSys. (2010) 6, 65-80.
- Jennifer S. Haghpanah, Carlo Yuvienco, Deniz E. Civay, Hanna Barra, Peter J. Baker, Sachin Khapli, Natalya Voloshchuk, Susheel K. Gunasekar, Murugappan Muthukumar & Jin K. Montclare, Artificial protein block copolymers comprised of two self-assembling domains. ChemBioChem. (2009) 10, 2733-2735. *Highlighted in Futurity* http://futurity.org/
- Zhiqiang Liu, Yuying Gosser, Peter James Baker, Yaniv Ravee, Ziying Lu, Girum Alemu, Huiguang Li, Glenn L. Butterfoss, Xiang-Peng Kong, Richard Gross & Jin K. Montclare, Structural and functional studies of A. oryzae cutinase: Enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation. J. Am. Chem Soc. (2009) 131, 15711-15716.
- Susheel K. Gunasekar, Mukta Asnani, Chandani Limbad, Jennifer S. Haghpanah, Wendy Hom, Hanna Barra, Soumya Nanda & Jin K. Montclare, N-terminal aliphatic residues dictate the structure, stability and assembly of the coiled-coil region of COMP. Biochemistry. (2009) 48, 8559–8567.
- Natalya Voloshchuk, Anita Yuhua Zhu, David Snydacker & Jin K. Montclare, Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity. Bioorg. Med. Chem. Lett. (2009) 19, 5449-5451.
- Sachin Khapli, Jin R. Kim, Jin K. Montclare, Rastislav Levicky, Mauricio Porfiri and Stavroula Sofou. Frozen cyclohexane-in-water emulsion as a sacrificial template for the synthesis of multilayered polyelectrolyte microcapsules. Langmuir, (2009) 17, 9728-9733.
- Jin K. Montclare*, Soojin Son*, Ginevra Clark, Krishna Kumar & David A. Tirrell, Biosynthesis of stable dimeric coiled-coils bearing (2S, 4R)-5’,5’,5’-trifluoroleucine and (2S, 4S)-5’,5’,5’-trifluoroleucine. ChemBioChem (2009) 10, 84-86. * these authors contributed equally
- Susheel K. Gunasekar, Jennifer S. Haghpanah & Jin K. Montclare, Assembly of bioinspired protein fibers. Polymers for Advanced Technology. (2008) 19, 454-468.
- Natalya Voloshchuk, Man Xia Lee, Wan Wen Zhu, Ismet Caglar Tanrikulu & Jin K. Montclare, Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: improved thermostability by a single-isoleucine mutant. Bioorganic Medicinal Chemistry Letters (2007) 17, 5907-5911.
- Tatyana Panchenko, Wan Wen Zhu & Jin K. Montclare, Influence of global fluorination on chloramphenicol acetyltransferase activity and stability. Biotechnology and Bioengineering (2006) 94, 921-930.
- Jin K. Montclare & David A. Tirrell, Evolving proteins of novel composition. Angewandte Chemie International Edition (2006) 45, 4518-4521.
Authored + Edited Books
*Peter James Baker*, Jennifer S. Haghpanah* & Jin K. Montclare Elastin-basted Protein Polymers. In Polymer Biocatalysts and Biomaterials II (2008) Edited by H. N. Cheng and R. A. Gross. Chapter 3.* these authors contributed equally
Favorite Books + Authors
Oliver Sachs
Favorite Movies
Rushmore
Biography
Jin Kim Montclare is an assistant professor in the Department of Chemical and Biological Sciences, who is performing groundbreaking research in engineering proteins to mimic nature and, in some cases, work better than nature. She works to customize artificial proteins with the aim of targeting human disorders as well as tissue regeneration and to produce environmentally-friendly catalysts that can readily degrade plastics. Using multidisciplinary expertise in chemistry and genetic engineering, these results have already been realized.
Prior to joining NYU-Poly, Montclare was a postdoctoral fellow at the California Institute of Technology in the Division of Chemistry and Chemical Engineering.
She received a Bachelor of Science in Chemistry from Fordham University in 1997, a Master of Science and a PhD in Bioorganic Chemistry from Yale University in 2001 and 2003, respectively.
Among her many honors and awards are the American Chemical Society PROGRESS /Dreyfus Lectureship, the Dreyfus Special Grants Program Award, the Air Force Office of Scientific Research Young Investigator Award, the Wechsler Award for Excellence, the Othmer Junior Fellow Award, the National Institute’s of Health Postdoctoral Fellowship, and the National Science Foundation Pre-doctoral Fellowship.
Montclare is the author of numerous papers for refereed journals, colloquia, and seminars and holds two patents.
She is a member of the American Chemical Society, the International Society for Pharmaceutical Engineering, the Biophysical Society, the Materials Research Society, the Biochemical Society, the Protein Society and American Association of Cancer Research, and the American Institute of Chemical Engineers.