Jin Ryoun Kim
Associate Professor
Chemical and Biomolecular Engineering
- Phone: (718) 260-3719
- Email: jkim@poly.edu
- Location: RH 816B
- Website:
Education
Johns Hopkins University, Class of 2006
Postdoctoral Fellow,
University of Wisconsin, Class of 2004
Doctor of Philosophy, Chemical and Biological Engineering
Seoul National University, Class of 1999
Master of Science, Chemical Engineering
Seoul National University, Class of 1997
Bachelor of Science, Chemical Engineering
Courses Taught
CBE 3153 Chemical and Biological Engineering Thermodynamics (Fall)
CBE 6813 Chemical Reactor Analysis and Design (Spring)
CBE 8813 Biochemical Engineering (Spring)
Research Interests
Protein engineering for therapeutic purpose Protein folding and stability
Creation of protein-based biosensor Design of an in situ molecular sensor for different aggregates species generated in Alzheimer's and Parkinson's disease
Characterization of protein aggregation
Development of mutation-free protein thermostabilization methods
Grants
NSF BBBE, NSF Biosensing, NSF MRI, Alzheimer's association, ()
Journal Articles
- Vandan Shah, Brennal Pierre and Jin Ryoun Kim, "Facile construction of a random protein domain insertion library using an engineered transposon", Analytical Biochemistry, in press (2012)
- Ahra Ko and Jin Ryoun Kim, "Effects of intramolecular distance between amyloidogenic domains on amyloid aggregation", International Journal of Molecular Sciences, 13: 12169-12181 (invited contribution) (2012)
- Mary K Cowman, Michael Hernandez, Jin Ryoun Kim, Han Yuan and Yang Hu, "Macromolecular Crowding in the Biomatrix", Structure and Function of Biomatrix: Control of Cell Function and Gene Expression, edited by E.A. Balazs and M. Hargittai, Matrix Biology Institute in Edgewater, NJ, in press (2012)
- Yang Hu, Baihao Su, HeQiu Zheng and Jin Ryoun Kim, "A peptide probe for detection of various beta-amyloid oligomers", Molecular BioSystems, 8:2741-2752 (2012)
- Yang Hu, HeQiu Zheng, Baihao Su and Jin Ryoun Kim, "Modulation of beta-amyloid aggregation by engineering the sequence connecting beta-strand forming domains", Biochimica et Biophysica Acta - Proteins and Proteomics, 1824:1069-1079 (2012)
- Michael Hernandez, Sofia Golbert, Li Guo Zhang and Jin Ryoun Kim, "Creation of aggregation-defective alpha synuclein variants by engineering the sequence connecting beta strand forming domains", ChemBioChem, 12:2630-2639 (2011)
- Joon Ho Ahn, Yang Hu, Michael Hernandez and Jin Ryoun Kim, "Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers", Biochemical and Biophysical Research Communications, 414:79-83 (2011)
- Jung-Eun Cho and Jin Ryoun Kim, "Recent approaches targeting beta-amyloid for therapeutic intervention of Alzheimer's disease", Recent Patents on CNS Drug Discovery (invited review), 6:222-233 (2011)
- Brennal Pierre, Tina Xiong, Leonie Hayles, Visweswara Reddy Guntaka, and Jin Ryoun Kim, "Stability of a guest protein depends on stability of a host protein in insertional fusion", Biotechnology & Bioengineering, 108(5):1011-1020 (2011)
- Yang Hu, Baihao Su, Chung-Sei Kim, Michael Hernandez, Agueda Rostagno, Jorge Ghiso, and Jin Ryoun Kim, "A strategy for designing a peptide probe for detection of beta-amyloid oligomers", ChemBioChem,11: 2409-2418 (2010)
- Chung-Sei Kim, Brennal Pierre, Marc Ostermeier, Loren L. Looger and Jin Ryoun Kim, "Enzyme stabilization by domain insertion into a thermophilic protein", Protein Engineering, Design & Selection, 22:615-623 (2009)
- Sachin Khapli, Jin Ryoun Kim, Jin Kim Montclare, Rastislav Levicky, Maurizio Porfiri and Stavroula Sofou, "Frozen Cyclohexane-in-Water Emulsion as a Sacrificial Template for the Synthesis of Multilayered Polyelectrolyte Microcapsules", Langmuir, 25: 9728?733 (2009)
- Jing Liang, Jin Ryoun Kim, James T. Boock, Thomas, J. Mansell, Marc Ostermeier, "Ligand binding and allostery can emerge simultaneously", Protein Sci. 16: 929-937 (2007).
- Jin Ryoun Kim, Todd J. Gibson, Regina M. Murphy, “Predicting solvent and aggregation effects of peptides using group contribution calculations”, Biotechnoogy Progress, 22:605-608 (2006).
- Jin Ryoun Kim, Marc Ostermeier, “Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase”, Archives of Biochemistry and Biophysics, 446:44-51 (2006).
Biography
Jin Ryoun Kim is performing research in the creation of novel proteins for complex functionality such as the design of a protein sensor for detection of toxic molecules in neurodegenerative diseases and the development of a highly-stable enzyme that can be used in industry. His work has been recognized as significant by prestigious scientific societies and magazines.
He joined the faculty of Polytechnic Institute of NYU in 2006 as an assistant professor in the Department of Chemical and Biological Engineering.
He earned a Bachelor of Science (with honors) and a Master of Science in Chemical Engineering from Seoul National University in 1997 and 1999, respectively and a PhD in Chemical and Biological Engineering from the University of Wisconsin-Madison in 2004.
Kim has authored manyl journal articles and patents and is a member of the American Institute of Chemical Engineering, the American Chemical Society, the Protein Society, and the New York Academy of Sciences.
He is the recipient of the New Investigator Award from the Alzheimer’s Association (2009-2011) and the Wechsler Award for Excellence (2009).