Research at Polytechnic is conducted either through academic departments or through one of many interdisciplinary research centers listed below:

• Center for Advanced Technology in Telecommunications (CATT)
• Center for Biocatalysis & Bioprocessing of Macromolecules
• Center for Drug Delivery Research (CDDR)
• Center for Finance and Technology (CFT)
• Center for Technology in Supply Chains and Merchandising (CTSCM)
• Institute for Mathematics and Advanced Supercomputing (IMAS)
• Institute for Technology and Enterprise (ITE)
• Othmer Institute for Interdisciplinary Studies
• Polymer Research Institute (PRI)
• Transportation Research Institute (TRI)
• Urban Intelligent Transportation Systems Center (UITSC)
• Urban Security Initiative
• Urban Utility Center
• Wireless Internet Center for Advanced Technology (WICAT)