Staff > group members > Dr, Wenhua Lu > resume

Dr, Wenhua Lu

born on 01/06/1978in Weifang, P.R.China
Postdoctoral , joined in Aug, 2005
Room No.:RH731

Phone: 718-260-4097
Fax: 718-260-3075
Email: wh_lv@yahoo.com

Current Work:

Engineering of Candida tropicalis for ω-hydroxylation of fatty acids (DARPA project: Bioengineering fuel-latent plastics and their conversion to biodiesel).

Long-chain ω-hydroxyfatty acids are used as the monomers that mimic the structure of biodiesel to synthesize a new family of fuel-latent plastics. The plastics will have properties similar to polyethylene but can be degraded by enzyme. After their use they will be shredded and efficiently converted by a mild enzymatic process to provide liquid biodiesel.

In collaboration with DNA 2.0, our lab is developing a whole cell biotransformation process for the conversion of long chain saturated fatty acids to ω-hydroxyfatty acids efficiently and specifically, including the construction of engineered Candida tropicalis using protein engineering (DNA 2.0), screening/testing of the engineered P450 variants, and optimization and process control of fermentation, to obtain the high yield and productivity of ω-hydroxyfatty acids.

CV:

Education:

2000-2005 Ph.D, Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P.R.China.

1996-2000 B.S., Microbiology, ShanDong University, Jinan, Shandong Province, P.R.China.

Professional Experience:

THE CANCER INSTITUTE OF NEW JERSEY New Brunswick, NJ

Principle Laboratory Technician 1999– 2002

Department of Pharmacology

ROCKEFELLER UNIVERSITY New York , NY

Research Assistant 2004-2005

Department of Immunology & Cell Physiology

Awards:

• First class Fellowship of Institute of Process Engineering
  
• 2002 Excellent graduate of Institute of Process Engineering

List of Publications:

• Wenhua L , Xiaoyan Z & Wei C. Modelling the production of nisin by Lactococcus lactis in fed-batch culture. Applied Microbiology and Biotechnology, 2005, 68(3), 322-326
  
• Wenhua L , Wei C & Zhaoling C. Effect of sucrose on nisin production in batch and fed-batch culture by Lactococcus lactis. Journal of Chemical Technology and Biotechnology, 2005, 80, 511-514
  
• Wenhua L , Wei C & Zhaoling C. Improvement of nisin production in pH feed-back controlled fed-batch culture by Lactococcus lactis Subsp. lactis. Biotechnology letters, 2004, 26(22), 1713-1716
  
• Wenhua L , Wei C & Zhaoling C. Nisin Production by Lactococcus lactis Subsp. lactis under Nutritional Limitation in Fed-Batch Culture. Biotecnology letters, 2004, 26 (3), 235-238
  
• Wenhua L , Wei Cong & Zhaoling C. The influence of sucrose, lactate and KH 2PO 4 on nisin production by Lactococcus lactis sub.lactis ATCC 11454. The Chinese Journal of Process Engineering, 2004, 4(1), 28-31
  
• Wenhua L Cuiying J, Xiaoyan Z, Wei Cong, Zhaoling C. Nisin production by feed-back controlled method. Patent, Application Number: 200420009076.2
  
• Wei C, Wenhua L, Ruijuan K, Zhaoling C. Air-lift photic bioreactor. Patent, Application Number: 200410046394.0