This course introduces modern protein engineering techniques available to researchers to understand protein structure and function and to create entirely new proteins for a variety of purposes. This is a new field that lies on the interface of chemistry, biology and engineering. The first part of the course discusses protein composition and structure and various genetic, biochemical and chemical techniques required to engineer proteins—all followed by specific topics. Topics include designing proteins that are highly structured and active at high temperatures and in non-aqueous solvents; that selectively interact with other proteins, small molecules and nucleic acids for therapeutic purposes; and that catalyze new reactions.
Prerequisite: CM9413 or adviser’s approval.