The course covers fundamental concepts in drug delivery from an engineering perspective. Biological organisms are viewed as highly interconnected networks where the surfaces/interfaces can be activated or altered chemically and physically/mechanically. The course focuses on the importance of intermolecular and interfacial interactions on drug-delivery carriers. Topics include drug-delivery mechanisms (passive, targeted) for metastatic cancer, in particular, and for inflammatory-type-of-diseases, in general; therapeutic modalities and mechanisms of action; engineering principles of controlled release and quantitative understanding of drug transport (diffusion, convection); effects of electrostatics, macromolecular conformation and molecular dynamics on interfacial interactions; thermodynamic principles of self-assembly; chemical and physical characteristics of delivery molecules and assemblies (polymer based, lipid based); significance of biodistributions and pharmacokinetic models; toxicity issues and immune responses.
Prerequisite: CBE 3313 and CBE 3323 or adviser’s approval.